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Health

Restoring the brain’s mitochondria could slow ageing and end dementia

The discovery that faulty metabolism is at the root of many brain diseases suggests a surprising transplant could be the way to protect our brains from the ravages of ageing

By David Robson

8 March 2023

TXBTRF 3d rendered medically accurate illustration of amyloid plaques on a alzheimer nerve cell

Protein plaques in the brain may be caused by failing mitochondria

Sebastian Kaulitzki/Alamy

IF YOU own a car, you will have noticed the engine getting less efficient with time. The further you drive it, the more fuel it takes to make the same journey – until, eventually, it becomes so underpowered that it needs a physical push to climb even a gentle hill.

Now, it is emerging that much the same is true of the human brain. Microscopic structures called mitochondria, found in every brain cell, are quite literally the engines of our thoughts and feelings. As we age, they find…

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