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Health

We’re finally learning how perimenopause profoundly changes the brain

The hormonal upheaval in the run-up to menopause can cause cognitive difficulties. But researchers are also finding that this can be a critical window for protecting long-term brain health

By Linda Geddes

20 March 2025

·ï»Ë²ÊƱ. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

The first sign something was amiss was the tiredness. Then I started forgetting where I had left my phone or keys, only to find them in the fridge or kitchen cupboard. The breaking point came when I went to make a cup of tea before an important interview, only to return 45 minutes later to a string of increasingly irritated emails asking why I wasn’t on the call. I had been potting houseplants instead.

As a woman in my early 40s, I was aware of this thing called perimenopause looming. But were my symptoms related to this, or just a product…

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